Two sample MR report
SPATC1L_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0604741 | 0.0396951 | 0.1661454 |
| Weighted median | 10 | -0.0064693 | 0.0070085 | 0.3559730 |
| Inverse variance weighted | 10 | -0.0122421 | 0.0054440 | 0.0245290 |
| Simple mode | 10 | -0.0058276 | 0.0109690 | 0.6080864 |
| Weighted mode | 10 | -0.0058276 | 0.0106313 | 0.5969177 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.800194 | 8 | 0.9865365 |
| Inverse variance weighted | 5.220259 | 9 | 0.8147005 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0775686 | 0.0419439 | 0.1015792 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.2e-05 | 0 | TRUE | 0.391411 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
